Impacts of loading thymoquinone to gold or silver nanoparticles on the efficacy of anti-tumor treatments in breast cancer with or without chemotherapeutic cisplatin

Table 1 In vitro Inhibition IC₅₀ values (µg/ml) and in vivo LD₅₀ (mg/kg) of AuNPs/TQ, AgNPs/TQ composites on EAC cell line

NPs composites	In vitro IC₅₀ (µg/ml)	In vivo LD₅₀ (mg/kg)	In vivo sub-lethal doses (mg/mouse)
TQ	338	922	1.00
AuNPs	30	378	0.2
AuNPs + TQ	32	387	0.2
AgNPs	63	494	0.2
AgNPs + TQ	62	490	0.2

LD₅₀ values were calculated from In vitro IC₅₀ according to the equation: log (LD₅₀) = 0.372 × log (IC₅₀) + 2.024 (Halle 1998, 2003)

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