Table 3 Modeled distances between alpha carbon of R358 and S195 hydroxyl side chain in AAT M358R and variant encounter complexes
Name of inhibitor protein | Pka distance (Ã…) | FXIa distance (Ã…) |
|---|---|---|
AAT M358R | 11.5 | 3.3 |
7-QLIPS-3 | 4.4 | 4.9 |
7-FLIPS-3 | 6.3 | 8.7 |
7-FLEPS-3 | 3.3 | 3.6 |
7-FLEAS-3 | 3.4 | 3.1 |
2-VRRAY-3ʹ | 12.8 | 18.2 |
2-PRRAY-3ʹ | 27.1 | 43.9 |
2-PRSAY-3ʹ | 27.0 | 23.9 |
2-PRSIY-3ʹ | 23.4 | 15.0 |
7-QLIPSVRRAY-3ʹ | 15.6 | 54.9 |