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Table 3 Minimal fungal inhibitory concentration (MFIC) and minimal lethal fungal concentration (MLFC) of the Pyrazole 3b compound following a 72 h incubation period at 28 °C

From: Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives

Pyrazole 3b

(Conc. µg/ml)

A. niger ATCC 11414

A. flavus ATCC 9643

Activity spectrum

Minimum fungicidal inhibition concentration (MFIC)

1000

-

-

2/2 (100%)

500

-

-

2/2 (100%)

250

-

-

2/2 (100%)

125

+

+

0/2 (0%)

Dose of MFIC (µg/ml)

250

250

 

Minimum lethal fungal concentration (MLFC)

1000

-

-

2/2 (100%)

500

-

-

2/2 (100%)

250

+

+

0/2 (0%)

125

+

+

0/2 (0%)

Dose of MLFC (µg/ml)

500

500

 

Antifungal effect

2

2

 
  1. - = No detected growth, + = Growth observed. Results according to averages 3 replicates, Fungicide agent = ≤2 and Fungistatic agent = ≥2