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Table 1 The kinetics models of ARI release from NIOs/ARI

From: Aripiprazole-loaded niosome/chitosan-gold nanoparticles for breast cancer chemo-photo therapy

Kinetics model

Equation

Coefficient of determination (R2)

pH = 5.8

pH = 7.4

Zero-order

\(F={k_0}{\kern 1pt} t\)

0.8576

0.7367

First order

\(\ln (1 - F)= - {k_f}{\kern 1pt} t\)

0.9322

0.7844

Higuchi

\(F={k_H}\sqrt t\)

0.969

0.8811

Power lawa

\(\ln F=\ln {k_P}+P\ln t\)

0.9903

0.9516

Square root of mass

\(1 - \sqrt {1 - F} ={k_{1/2}}{\kern 1pt} t\)

0.8977

0.7609

Hixson-Crowell

\(1 - \sqrt[3]{{1 - F}}={k_{1/3}}{\kern 1pt} t\)

0.9099

0.7688

Three seconds’ root of mass

\(1 - \sqrt[3]{{{{(1 - F)}^2}}}={k_{2/3}}{\kern 1pt} t\)

0.8849

0.7529

Weibullb

\(\ln ( - \ln (1 - F))= - \beta \ln {t_d}+\beta \ln t\)

0.9937

0.9618

Reciprocal powered timec

\(\left( {\frac{1}{F} - 1} \right)=\frac{m}{{{t^b}}}\)

0.9885

0.9701

  1. apH = 5.8: kP=0.1645 and P = 0.2315; pH = 7.4: kP=0.0955 and P = 0.2708
  2. bpH = 5.8: β = 0.2661 and td=615.2458; pH = 7.4: β = 0.2948 and td=2391.1066
  3. cpH = 5.8: m = 4.9973 and b = 0.3046; pH = 7.4: m = 9.3633 and b = 0.3204