Fig. 3
From: Design of a novel multi-epitope vaccine against Marburg virus using immunoinformatics studies
Immune responses to MARV including antibodies (A), cytokines (B), B cells (C and D) and T cells (E-I). Accordingly, the antibodies levels enhanced nearly two weeks after antigen exposure (A). Additionally, highest increase in cytokines levels included for IFN-b and TGF-b five to 15 days post-vaccination (B). The increase in the number of B cells including memory cells and IgM, IgG1 and IgG2 isotypes and active B cells was predicted after 2–3 days of vaccination (C, D). Moreover, T cells populations but not anergic cells enhanced following 2–3 days of vaccination. TH cells including total TH and TH1 cells mostly increased 2–3 days after vaccination (E, F). Additionally, the enhanced percentage of TH1 cells continued for more than a month (G). Not memory TC cells count increased 2 days after vaccination and maximized 7–17 days and then decreased to day 28 and increased again 28–31 days. Active TC cells number increased following 2–3 days after vaccination and memory TC cells had a stationary state during the simulation