Fig. 7

Combination of A2 and SO1861 allows dose reduction. The upper half of the schematic image shows the use of DAES alone, while the lower half depicts the combination of SO1861 and the adapter-consisting construct DAES. The combination allows substantial dose reduction of the targeted toxin, resulting in much fewer toxin molecules binding to healthy cells and thus reducing undesired toxicity. Simultaneously, the toxic effect towards cells that express high levels of EGFR is maintained since SO1861 and the adapter mediate endosomal escape